After all the questions that I have asked, I am actually asking one now for a friend. My friend's mother, 76, Asian heritage, out of state, has now been diagnosed with NSCLC adenocarcinoma, EGFR Exon 18, Stage IV - metastatic multiple locations. My friend says the insurance company will not pay for TKI treatment, since they have not been found effective for Exon 18, and is only paying for palliative radiation.
My question is regarding the current state of TKI treatment for Exon 18. I read several articles saying that TKIs are much less effective for Exon 18, but a couple of the articles suggested that one or two of the 2nd generation TKIs (even more than the 3rd ben TKIs), like afatanib, have shown some effectiveness for Exon 18. I just wondered if you had any sense of the current state of thinking for types of treatments used for Exon 18.
Any info that might help my friend discuss this with the insurance company (if indeed any TKIs have shown some effectiveness for Exon 18) would be helpful.