I just want to share with you all the recent developments on my father's disease.
So far, we have gone through 2 cycles of Taxotere, which for now is being given at 75% of the 75mg/m2 dose, i.e. about 60mg/m2. Side effects are being fairly manageable, with some fatigue and nausea limited to days 4-8 after the infusion. He also takes Prednisone 25mg as a 3-day medication before, during and after the treatment, rabeprazole once a day for the whole period and metoclopramide when required. Taxotere is given with ondansetron, ranitidine and dexamethasone 8mg.
Leukopenia is being mild, with WBC count going down to 3.5k/uL about 7 to 10 days after the infusion, but going back up to normal values before the next round.
For round #3 and #4 we will probably try to go up to the 100% of the Taxotere dose.
Last week, dad had an MRI to his head to better understand the status of the cerebral mets that were identified with the last CT scan. Results: 2x lesions (6mm and 7mm) confirmed on the left side and a 3mm micro-lesion detected on the right side.
In addition to this, it is reported:
- local leptomeningeal strain (?) of the perilesional furrow (?) of the 6mm lesion (I've tried to translate)
- multiple minor gliotic areas
We will discuss this with our oncologist, but I cannot hide my concern with that "leptomeningeal".
Is there enough data to think about leptomeningeal carcinomatosis? Apart from some fatigue and a few episodes of dizziness over the last months, dad's conditions are pretty good.
And what are the gliotic areas?
Thanks for your support.