Dear Dr. West:
I have been reading and listening to everything you have to say about the efficacy of all the new immunotherapy drugs that are coming on the market. Your podcasts are so encouraging for those of us who are now diagnosed as advanced stage lung cancer. My lung cancer has metastasized to the bones in particular my right hip, SI joint, and areas of the spine. I am now enrolled in an Astra Zeneca Clinical Trial titled Mystic.
I know the reason for the trial is to asses the efficacy of these two drugs, of course. I have a few questions, I hope you can answer from what you MAY now know about these two drugs given singly or together.
1. Can you tell me anything about each of these drugs?
2. What is your opinion about these drugs being given together?
3. How does the PDL-1 mutation play into a factor with each? And is there a range of expression for the PDL-1 mutation.
4. I am also on a monthly injection of XGEVA. Your thoughts?