nsclc stage 4, non-smoker, non-squamous EGFR+ and also PDL1+ - 1269985

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bigbill
nsclc stage 4, non-smoker, non-squamous EGFR+ and also PDL1+ - 1269985

Anyone else out there been told they are both egfr+ and have the PDL1 biomarker? just curious

catdander
I'm not sure PDL1 and

I'm not sure PDL1 and mutations are in the same group. Mutations cause the cancer to grow where PDL1 stops the immune system from seeing and attacking the tumor. So it's likely that it's not that unusual but more along to lines of PDL1 being a new trigger being followed in immunotherapies. We have an excellent presentation on immunotherapies (Note that the title is squamous but has excellent information in both video that are relevant to both squamous and adeno, including a very good explanation of nsclc in general, in two videos starting with this one, http://cancergrace.org/lung/2015/02/17/lsc201_understanding_your_lung_sq... Note at around the 11:00 minute the list of known mutations in nsclc.

In the second video also at around the 11:00 minute mark Dr. Pecot explains PDL1 protein created by the tumor that blocks the immune system.

I think you're in pretty good luck to have both because both are targetable.

I hope this helps and very much luck to you,
Janine

cards7up
Are you sure you have

Are you sure you have squamous? Since it would be very rare to be EGFR positive for that mutation, it's normally in adenocarcinoma. Take care, Judy