PD-1 Video Dr. Wolchok - 1257166

Most of you have probably already have seen this video but this is good explanation of how PD-1 & PDL-1 can potentially work: From ASCO 2013. Copy and paste in your web browser.

http://chicago2013.asco.org/dr-jedd-d-wolchok-pd1-pathway-activity-nove…

Wife 64 never smoker 12/11-DX NSCLC Aden, small left pleural eff
12/9/11-CT scans-3cm mass left lung,”innumerable nodules in both lungs under 5mm”
12/20/11-PET scan 3cm lower left lung mass, mets both lungs, extensive osseous mets
12/14/11-biopsy-neg for EFGR,ALK,KRAS,BRAF mutations
12/21-Begin Alimta(pemetrexed) 3 wk intervals
2/12-MRI brain,2 lessions 2.5mm&2.0mm,not appear to be brain mets
3/12-7/12- 4 chest x-rays,left lung mass sig reduced,”tiny nodules both lungs”,no pl eff
12/11-8/12-blood serum markers CEA 403.7 to 8.9,CA-19 5210 to 32
12/11-10/24/12 - 14 sessions of Alimta in 3 wk intervals
1/7/13 – CT scan stable – No progression
12/24/12-4/20/13 – Chemo Break
2/20/13 – 4/10/13 significant CEA increase
4/10/13 – present - 3 more sessions of Alimta