Dear all - my mother aged 66, has been diagnosed with Poorly differentiated Pulmonary Adenocarcinoma of the lung. Her PET Scan findings are as follows:
- Moderate right pleural effusion with passive collapse of the underlying lung
- 1.9 x 1.6 cm metabolically active lobulated soft tissue lesion in the anterior segment of the right upper lobe - ? the primary focus of neoplasm
- Metabolically active focal lesions in the collapsed right lower lobe and right middle lobe - ? synchronous primary foci v/s metastases
- Metabolically active right lower peribronchial, right hilar, subcarinal, precarinal, pretracheal, right paratracheal and right anterior supradiaphragmatic lymph nodes – metastatic
- Multiple soft tissue nodules along the right parietal and visceral pleura – metastatic
- Subtle soft tissue nodularity of the left pleural reflection, interval follow up is recommended
- Metabolically active focal lesions in the left proximal humerus and proximal sternum - metastatic
We tested for EGFR and ALK mutation. EGFR came negative, while ALK D5F3 was positive.
Her doctor has started first line Chemo - Pemetrexed (900mg - Day1) + Carboplatin (530mg - Day 2) and Pegrafeel on Day-3. She is also prescribed Decmax, Folic acid and Pan D for 5 days to control the side effects.
She has completed first cycle, and she has handled the treatment rather well, and her symptons have subsided. Her Doctor has indicated that he would like to continue the first line Chemo for 4 cycles and switch to oral meds since she is ALK positive.
Am looking to hear from other in a similar situation, on the treatment approach taken. Any pointers for clinical trials for Alecnitib that she would be eligible for, would also be appreciated.