Just under two weeks ago (1/13), we were excited to learn that my husband, Gary, has the ROS1 rearrangement. Unfortunately, two days later he was hospitalized for shortness of breath and underwent placement of an indwelling pleural drain and use of a pump for treatment of a hydropneumothorax. This did not improve his symptoms, and on 1/21 he was discharged with home oxygen and a diagnosis of Systemic Inflammatory Response Syndrome. He still feels at least as poorly as he did prior to hospitalization.
On 1/16, while Gary was hospitalized, his onc agreed to order crizontinib for him with hopes that he would be feeling better after the inpatient treatment. Now Gary feels that it may be too late to have crizotinib do him any good.
My questions are:
1. What does it mean and what are the implications of having SIRS in this situation?
2. In this situation does SIRS get better?
3. Is it likely that crizotinib would worsen the SIRS?
3. Is it reasonable for Gary to believe that it is too late to receive a worthwhile benefit from crizotinib?
I am not asking for medical advice on what we should do. I am asking for a bit more information on SIRS and how crizotinib may impact it and Gary's quality of life. Hopefully these are appropriate questions. I searched and was not able to find related information on the site.
As always, thank you so much for your help,