Well, here we are, barring any last minute complications my wife should start the TAK-788 trial next week. She has already had her main blood work and a CT scan. All she needs now is an updated brain MRI and a blood test for magnesium and bilirubin.
The trial oncologist sounded very optimistic, and said they were having good success with the drug so far (as Jim posted with the ASCO results). Main side effects so far have apparently been diarrhea and an acne-like rash (especially for people who spend time in the sun). And no steroids! So hopefully less sleepless nights and a bit less heartburn (although you can't take any acid reducers on this trial, probably worried about effects on drug uptake since it is a pill). It's a small molecule TKI, designed to bind more tightly to the Exon20 mutations than to the normal EGFR or HER2. And apparently the EGFR cohort for the trial is full, but they need more HER2 patients, so my wife is once more plunging in to help science!
So onward we go - treatment line #5. I'll update after next week (for first day of trial my wife has to spend all day at U of C - the drug in the morning and blood draws every hour to measure release of drug into bloodstream).