Hi, Grace Community. I've just officially joined the site, although I've been a frequent reader of the threads here off and on for several years. Thanks to everyone for posting your experiences on here. It's often helpful to read about other people's treatment regimens and experience with side effects, etc. We're trying to decide on next steps for my mom's treatment by next Monday, and I was hoping to get some input from anyone with experience in treatments after acquired resistance to Tarceva (specifically with T790M mutation, if possible). We were hoping to put my mom in an Afatinib/Cetuximab trial, but unfortunately that doesn't seem to be an open option right now. Her oncologist has presented us with the following options: 1) Chemo (Carboplatin, Alimta, and Avastin), 2) Afatinib only, or 3) Adding Avastin to her current dosage of Tarceva. I'm aware that there is no definitive treatment identified for post-acquired-resistance to Tarceva, but wondered if anyone here has experience with any of the three options mentioned above (or the afatinib/cetuximab trial, for that matter)? The afatinib only option doesn't seem very promising for a second line treatment for those who have acquired resistance to Tarceva when you read about it, so it's looking increasingly like chemo is our best option. My mom is understandably concerned about starting chemo since she's been able to maintain a pretty normal lifestyle managing the side effects from Tarceva (dry skin, rash, bad toes, scalp issues, and diarrhea). If anyone out there has some insight to the chemo option and how well it was tolerated, or other options that have worked well post tarceva resistance, we would greatly appreciate it! Thanks in advance.
Thu, 10/18/2012 - 15:03#1
Treatment after acquired resistance to Tarceva - 1249220