I am writing for your advice whether my mother should get Cyberknife treatment. Some doctors suggested Cyberknife as a non-invasive treatment. But another doctor suggests wait-and-see, since the growth is slow. My parents are hesitant. They are concerned that Cyberknife may stimulate the growth of any residual cancerous cells if the ablation is not complete and things become even worse.
Below is a brief description of her history.
A 62-year old Chinese female, life time non smoker.
Multiple-spot nodes were detected in the right lung in 10/2005 when she was 54 during a regular body check-up, and confirmed through a biopsy as BAC in Nov. 2005. Surgery was not an option because of multiple spots.
11/2005 - 06/2006: 8 rounds of chemotherapy:
4 rounds of Gemzar + cis-Dichlorodiamineplatinum(II) + 4 rounds of Paclitaxel + Carboplatin (CBP).
One month after (08/2006), the growth of the tumors was detected and Gefitinib tablets (Iressa) have been prescribed by the physician since then. Iressa had been working well. The largest node remained the same and small ones shrank in size or disappeared from CT scans.
2011, cut Iressa dose in half.
However, the largest tumor was found to grow in 04/2012. She took four rounds of chemotherapy (Alimta/Pemetrexed disodium + Carboplatin) (11/2012 - 01/2013). The first two rounds seemed to work modestly, but the third and fourth didn't seem to work so she stopped the regimen.
Now she had increased Iressa to 1.5 tablets/day.
The present condition:
- The largest tumor is 52*35mm, and there are a few small ones.
- No metastasis is detected (by PET-CT, MR).
- All the results of blood laboratory tests are normal.
- CEA has been rising since 2008 (from 3.78 to 12.75 in 03/2013, dropped to 11.77 in 04/2013)
I have a couple more specific questions. Is her node size suitable for Cyberknife? Are there any targeted drugs that might benefit her?
Thank you for reading through. My parents and I will value any advice.