Unfortunately I think my mother has to be one of the most easily resistant ALK+ NSCLC patient ever. After spending less than 4 months on Xalkori, she is now resistant to a 2nd generation ALK Inhibitor Chugai CH5424802 in less than two months.
It is especially disappointing considering that my mother had a 30% reduction in her first scan, the results were so good that the company actually requested a second set of CTs to confirm the shrinkage. Her adrenal met vanished and became unremarkable.
However less than a month since that first faithful scan, her cancer has progressed once again, with her liver tumor growing about a centimer, and one of her lung nodules increasing in size as well.
While her oncologist recommends moving on to another 2nd generation ALK inhibitor (LDK378) I am especially concerned with the two week washout period considering how aggressive my mother's cancer is.
As a result If anybody can provide advice in regards to treating my mother's liver met locally first would be a good idea. Either through RFA, cyberknife, Cryoablation, I just to have something done instead of waiting.