As part of the 2025 Blood Cancer Video Library, where oncologists discuss the most emerging treatment options and information in blood cancer, Dr. Shaji Kumar (Mayo Clinic) discusses optimal strategies for the treatment of newly diagnosed multiple myeloma (MM).

The article describes the AVO treatment, a combination therapy for Chronic Lymphocytic Leukemia (CLL), particularly for high-risk patients. CLL is a slow-growing cancer where abnormal white blood cells accumulate. "High-risk" CLL refers to cases with specific genetic changes (e.g., in TP53) that make the disease harder to treat.