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Third Generation EGFR TKIs for Acquired Resistance

Video

Dr. Nathan Pennell, Cleveland Clinic, discusses the concept of acquired resistance and new agents designed to address it, including Rociletinib and Merelitinib.

  • Read more about Third Generation EGFR TKIs for Acquired Resistance

Are There Clinically Significant Differences Among the Third Generation EGFR Inhibitors?

Article

Drs. Ben Solomon, Leora Horn, & Jack West compare the clinical data with the third generation EGFR TKIs so active in acquired resistance and consider whether there are significant differences between them.

  • Read more about Are There Clinically Significant Differences Among the Third Generation EGFR Inhibitors?

Are There Clinically Significant Differences Among the First and Second Generation EGFR TKIs (Iressa, Tarceva, Gilotrif)?

Article

Drs. Ben Solomon, Leora Horn, & Jack West review whether the data and clinical experience suggest any clinically significant differences among the first and second generation EGFR TKIs (Iressa, Tarceva, Gilotrif/Giotrif).

  • Read more about Are There Clinically Significant Differences Among the First and Second Generation EGFR TKIs (Iressa, Tarceva, Gilotrif)?

Should Third Generation EGFR Inhibitors Be Used Before First Generation EGFR TKIs or After Progression?

Article

Drs. Leora Horn, Ben Solomon, & Jack West consider whether third generation EGFR TKIs, so active in patients with acquired resistance, might be best used prior to development of acquired resistance.

  • Read more about Should Third Generation EGFR Inhibitors Be Used Before First Generation EGFR TKIs or After Progression?

Should EGFR TKI Therapy be Continued Beyond Progression?

Article

Dr. Greg Riely, medical oncologist from MSKCC, discusses the controversial question of whether patients should continue on an oral EGFR tyrosine kinase inhibitor after progression.

  • Read more about Should EGFR TKI Therapy be Continued Beyond Progression?

The Potential Value of Repeat Biopsies in Acquired Resistance

Article

MSKCC medical oncologist Dr. Greg Riely explains the growing value of a repeat biopsy after the development of acquired resistance in patients with an EGFR mutation.

  • Read more about The Potential Value of Repeat Biopsies in Acquired Resistance

Patterns of Acquired Resistance to EGFR TKIs in EGFR Mutation-Positive NSCLC

Article

Medical oncologist Dr. Greg Riely, MSKCC, summarizes the development of acquired resistance after a good initial response to EGFR inhibitor therapy and the clinical patterns of progression commonly seen.

  • Read more about Patterns of Acquired Resistance to EGFR TKIs in EGFR Mutation-Positive NSCLC
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  • FIGHT
    • Coping with Cancer
      • Just Diagnosed
      • In Treatment
      • In Remission
      • Survivorship
    • Cancer Information
      • Bladder Cancer
      • Blood Cancer
      • Breast Cancer
      • Head and Neck Cancer
      • Lung Cancer
      • Melanoma
      • Other
      • Latest Featured Content
      • The Archives
      • Other Resources
    • Find Clinical Trials
    • Glossary
      • Cancer FAQs
  • EDUCATE
    • Current Patient Education Video Series
      • Coronavirus and Covid 19 in the Cancer Community
      • Cancer Information for the Latino Community
      • 2020-21 Patient Education Ambassador's Program
    • GRACE Podcasts
    • Video Library
      • English
      • Spanish
      • Mandarin
  • PARTICIPATE
    • Community Forum
      • Bladder Cancer
      • Blood Cancer
      • Brain Cancer
      • Breast Cancer
      • Colorectal Cancer
      • Gall Bladder and Bile Duct Cancer (Cholangiocarcinoma)
      • Head and Neck Cancer
      • Kidney Cancer
      • Lung Cancer
      • Melanoma
      • Member Updates
      • General Forums
      • Ask A Question
    • Get Involved
      • Memorials and Tributes
      • Volunteer Opportunities
  • ABOUT CancerGRACE
    • GRACE NEWS AND INFO
      • Contact Us
      • How (and Why) to Use GRACE
      • GRACE Public Disclosure Documentation
    • About GRACE
      • Mission
      • Opportunities
      • Terms of Use
      • Our Supporters 2020
    • Our Team
      • Faculty
      • Staff and Board
    • Partnerships
      • GRACE and Clinical Care Options Patient Tools
      • Varian Partner Page 2020
      • Takeda Oncology Partnership Page 2020
      • Lilly Oncology Partner Page
  • DONATE
    • Why Give to GRACE
      • More Ways to Give
      • Corporate Giving Programs
      • Gifts of Stock or Securities
      • Shop and Search for the Cause
      • Create a Tribute
      • Create Your Own Fundraiser
      • Shop with GRACE