Lung Metastasis? - 1262263

cgmama
Posts:3

My father was diagnosed and successfully treated for stage iv oropharyngeal cancer in 2007. Cancer had spread to lymph nodes on left side of neck which were all removed. Following treatment he endured multiple surgeries and difficulties due to osteonecrosis of the right mandible which was rebuilt w his leg bone--flap failed and had a pectoral flap done. Following this he has had neck and chest wounds that will not heal. Before treatment in 07 he was 190 lbs-now down to 108 lbs w GI tube as he cannot chew/swallow solids. Wound care noticed infection coming from elsewhere and suspected a new tumor so they ordered a ct. Ct showed mass in right neck suspicious for malignant mass as well as a 3.1x4.2x2.8 cm subpleural noncalcified irregular mass in left pulmonary apex and a 2cm anterior subpleural mass in right lung base. He was referred for a full-body PET w CT attenuation. This showed suspicious changes throughout tongue, SUV 3.93; left lower lobe lung metastasis of 1.6cm with SUV 2.64, and right midsternal lytic metastasis of 2x2.9 cm with SUV 5.8. Obviously we are extremely concerned as the oncologist said lung or sternum metastasis means treatment would be palliative only. So, we were sent to his ENT who said his tongue showed no sign of recurrence whatsoever and who suspects the suspicious sternum area is infection due to the wound issue on his chest and that perhaps the lower left lung area is just inflammation or infection? Just really confused as to why the first CT and the PET/CT are so different and why the oncologist and the ENT would have such different takes on the imaging results..but really would just like to make some sense out of these results. Thank you so very much for your time and consideration.

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cgmama
Posts: 3

Also I should mention he hasn't smoked a cigarette since the early 70's, never drank. His cancer may have been hpv related.

JimC
Posts: 2753

Hi cgmama,

I think you're question just highlights the problem inherent with PET scans. They find cancer, infection and inflammation but can't distinguish between one or the other. There was a lot going on just before the scan, so it could be any of those possibilities.

Watching and waiting, biopsy and treatment with antibiotics are all possibilities at this point.

JimC
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Dr West
Posts: 4735

It's absolutely possible that areas of PET uptake could be infection and/or inflammation, but that pattern makes me very concerned that the surgeon may be painting an overly positive picture, perhaps because he hopes it will be the case. A biopsy would be the way to clarify what's going on.

Good luck.

-Dr. West

cgmama
Posts: 3

Thank you for your quick responses. I am so grateful for your input--it means a lot to me and my family.