Hello, My wife has been on Tarceva 13 mnoths dosage started at100mg, lower to 75mg and now at 50mg. At 50 there are still bouts of Diarrhea when these occur for more than a day, she stops a Tarceva for 2 or 3 days. Is stops the diarrhea attack. We have follow this course of action for the last 6 months and the blood work was been steady. In the last 2 to 3 months she has developed a problem with her hands. They have been painful and at night they curl up into a loose fist and need to be "forced opened". Can this be from the Taceva? Any exercises at may help?