sch1979
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Posts:11
My father has an EGFR exon 20 insertion mutation. We found out today that the PD-L1 was 60% which apparently is rare for an exon 20 insertion, but it means immunotherapy is an option. The treatment plan right now is keytruda, carboplatin, pemetrexed. Has anyone had this combination?
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Reply # - May 4, 2018, 05:27 AM
Hi sch1979,
Hi sch1979,
Since high PD-L1 expression is unusual for an exon 20 patient, there isn't specific data on the efficacy of this immunotherapy/chemo combination, but the early trial results were so good they led to FDA provisional approval: http://cancergrace.org/lung/2017/07/25/why-carboplatin-pemetrexed-and-p…
Another discussion of this combination therapy can be found here: http://cancergrace.org/lung/tag/keytruda/
I hope your father has great results with this regimen.
JimC
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