Hello to all
I have been on Carbo/ Alimta ( 5 ) and now 3rd Alimta maintenance after Tagrisso progression . Though I'm still on Tagrisso . Onc did not want to discontinue .
Ct after 4th carbo/alimta showed a medium response . Stable some and shrinking others.
Ever since maintenance alimta I get fevers on day 4 and a general flue like syndrome . This did not happen with the combo .The fevers and flue like symptoms last 1 1/2 weeks and then go away.Temp as high as 102.1 orally
I put myself into the ER for a workup and all was negative . Blood culture neg, CT showed slight progression
in the lung , no evidence of pneumonitis or pneumonia . Blood tests showed nothing to scary low .
I was released from the hospital and took Tylenol to stay functional . Without pushing the fever down I would be bed ridden .
This same reaction happened again the next time , after day 4 of infusion lasting 1/1/2 weeks .
The fever increases in the evenings and caused severe night sweats , headaches , muscle aches ,
dry cough ( I have radiation induced bronchiectasis and the lung is progressing slightly ) dizziness, nausea
I can't put myself into the ER after every infusion and go through the whole workup .
The progression is not severe enough to quit doctor said , but my quality of life is poor because of the symptoms and he would accept that decision.
I read there is such a thing as a flue like syndrome with a variety of cancer treatments . I developed something similar after irradiating the main lung mass a year ago and nothing unusual was found then either
The article claims it's a poorly understood phenomenon .
I have low grade autoimmune disease and am wondering if this could explain the reaction ?