anti-PDL-1 - 1255559

5 posts / 0 new
Last post
ssflxl
anti-PDL-1 - 1255559

this sounds like it's different from the other anti-PD-1 agents that were discussed.

http://health.yahoo.net/news/s/nm/roche-immune-therapy-cancer-drug-shows...

ssflxl

certain spring
Reply To: anti-PDL-1

Thanks for posting this, ssflxl.
I wish they'd just get on with it! The research, I mean ...

Dr West
Reply To: anti-PDL-1

Anti-PD-L1 is related to anti-PD1, blocking a different place in the same general pathway. There's plenty of reason to be hopeful about the agents against this target as well as nivolumab (BMS-936558) and other anti-PD1 agents in development. I'm sure that the companies are incentivized to move forward as quickly as they can, and investigators are certainly eager to participate in these trials when they can.

-Dr. West

+++++++++++++++++++++++++
Dr. Howard (Jack) West
Associate Clinical Professor
Medical Oncology
City of Hope Cancer Center
Duarte, CA

Founder & President
Global Resource for Advancing
Cancer Education

craig
craig's picture
Reply To: anti-PDL-1

Following up on that, at the ASCO conference earlier this month there was some early data on an experimental anti-PD-L1 drug MPDL3280A that looked surprisingly good (80% odds) for patients whose cancer expressed the PD-L1 target. (I'm always looking for anything well-targeted that is effective.) That seems better than the anti-PD1's, and seems "too good" so I can't help but want to go back and re-view the details more carefully when I can. Dr. West hosted that session, so he might be in an especially good position to size up for us which approaches and specific drugs from that session really seemed most promising.

http://meetinglibrary.asco.org/content/115901-132

Best hopes,

Craig in PA

_________________________________
Stage 4 ROS1+ [mucinous BAC] adenocarcinoma NSCLC since 2011
Xalkori (crizotinib) 5 yrs
Alimta (pemetrexed) + carboplatin (mere months)
TPX-0005 (repotrectinib) TBD (1+ years as of Fall 2018)

Dr West
Reply To: anti-PDL-1

Will follow-up with a post on this sometime soon.

-Dr. West

+++++++++++++++++++++++++
Dr. Howard (Jack) West
Associate Clinical Professor
Medical Oncology
City of Hope Cancer Center
Duarte, CA

Founder & President
Global Resource for Advancing
Cancer Education