My mom healthy 72 yo dx stage 4 Adneocarcinoma stage 4 with plural effusion in late Aug 2012.
Vats surgery. Sept insert plural catheter 3 month draining, vats surgery Dec. remove Catheter, significant progression, left lung solid mass tumor, no mets else where, 2 rounds carboplatin/ Alimta Finally enough tissue from second vats to do EGFR test positive Exon 19 . Possible infiltrates on chemo in good right lung.
Stop chemo, start Tarceva, ween off steroid use by end of 5 th day on Tarceva. Day 7 Tarceva hoarse voice, continues through day 9 coupled with extreme tiredness no appetite. Also beginning to experience more SOB Day 12 grade 1-2 rash appears on scalp and face. Day 13 begins cough and still no appetite,
Day 15 thinking it may be bronchitis, calls onc. Begins antibiotic Day 16 chest x ray shows former left lung that was solid tumor 3/4 open, dramatic response to Tarceva, good right lung looks like infiltrates. Day 18 chest x ray at onc shows infiltrates in good lung, confirms dramatic response in left lung with tumor, orders bronchoscopy. Waiting with worry. Mom's now on O2 24 hours and needs 4 liters, previous to taking Tarceva, she did take 2 liters O2 to give her a boost during the night.
Our Onc. does not think it is Tarceva related ILD since, it is happening so early in treatment.
My question is have any of you seen ILD early on in the use of Tarceva?
Since the Pulminologist could not definitively say it was not ILD, so the Onc. told her to stop Tarceva for 4 days do a CT on Monday while we wait for results from the Bronchoscopy.
Thanks for you Time,