From my reading, it appears that the oncological/hemotological world still does not know if chemos, particularly small molecule chemos like Alimta and Gemzar, pass the BBB to combat brain mets. Are autopsies not done on lung cancer patients? Can't an autopsy and chemical analysis of the brain reveal whether or not a chemo passes the BBB? What about all those who die during clinical trials, are they not autopsied to find out the role of chemo in the death, and to examine the brain and BBB to see if the chemo passed through? Why can't this question be answered definitively at this point of cancer research? When someone dies suspiciously and drugs are suspected, an autopsy is ordered by law enforcement authorities. And most of the time they get definitive answers. Is this not done when chemos are in clinical trials, or on those patients being followed for OS statistics later die? What am I missing here? When my mother died of cancer, clearly of cancer, her HMO still asked if we wanted an autopsy.
Mon, 12/03/2012 - 13:45#1
chemo and Blood Brain Barrier (BBB) - 1250910