I'm here for help as I'm feeling empty in spirit and soul.
My dad has a pleimorphic stage 4 non small cell lung cancer with sarcoma and mets
To liver and some bone areas. 1st Dx in Nov 2011.
Chemo treatments since 2011 with breaks in between are as followed:
Carbo / taxol / avastin / xgeva. 5 cycles ... Great results
cisplatin / avastin 2 cycles; side effects - he was becoming deaf so cisplatin removed to alimta. Total 4 cycles ... Ok results ( stable)
Docetaxel / avastin / xgeva - 6 cycles / ok results
Radiation therapy on shoulder
Radiation therapy on lung
Pet scan on jan 2014 revealed damage to his liver and less to his bone.
We'd be going now on a forth line of chemo; onco suggested a 4 chemo agents cocktail see article below:
Jpn J Clin Oncol. 2011 Mar;41(3):430-3. Epub 2010 Oct 5.
Two consecutive cases of platinum-refractory pulmonary pleomorphic carcinoma that showed dramatic responses to MAID (mesna, doxorubicin, ifosfamide and dacarbazine) chemotherapy.
Lee KW, Kim YJ, Kim JH, Bang SM, Chung JH, Lee JS.
I didn't think my Dad would survive this program (high toxicity but incredible results) so we sought a second opinion.
2nd onco told us about abraxane and gemzar. HAS ANYOne taken this dual therapy? Does it have a lessened toxic profile? i've read the significant results that this dual therapy had on pancreas cancer. Do the oncologist community on this site can comment if it has been administered to lung cancer?
Also learned about Clinoril (sudindac) http://www.news-medical.net/news/20100615/Sulindac-shuts-down-cancer-cel... for "...study reveals that Sulindac shuts down cancer cell growth by binding to nuclear receptor RXRα, a protein that receives a signal and carries it into the nucleus to turn genes on or off." Does the oncology community here use this drug too???
thank you for your interest in reading and replying,