keytruda, carboplatin, pemetrexed combo - 1294372

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sch1979
keytruda, carboplatin, pemetrexed combo - 1294372

My father has an EGFR exon 20 insertion mutation. We found out today that the PD-L1 was 60% which apparently is rare for an exon 20 insertion, but it means immunotherapy is an option. The treatment plan right now is keytruda, carboplatin, pemetrexed. Has anyone had this combination?

JimC
Hi sch1979,

Hi sch1979,

Since high PD-L1 expression is unusual for an exon 20 patient, there isn't specific data on the efficacy of this immunotherapy/chemo combination, but the early trial results were so good they led to FDA provisional approval: http://cancergrace.org/lung/2017/07/25/why-carboplatin-pemetrexed-and-pe...

Another discussion of this combination therapy can be found here: http://cancergrace.org/lung/tag/keytruda/

I hope your father has great results with this regimen.

JimC
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<p>I began visiting GRACE in July, 2008 when my wife Liz was diagnosed with lung cancer, and became a forum moderator in January, 2010. My beloved wife of 30 years passed away Nov. 4, 2011 after battling stage IV lung cancer for 3 years and 4 months</p>