PFS vs. pfs: Why Progression-Free Survival Remains Controversial in Lung Cancer Article Last year, an article came out in the Journal of Clinical Oncology that noted a gradual shift away from the "hard endpoint" of overall survival (OS) for lung cancer trials toward progression-free survival (PFS), a "softer endpoint" that is much more subject to interpretation. Read more about PFS vs. pfs: Why Progression-Free Survival Remains Controversial in Lung Cancer