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Translation of Molecular Genetics in Lung Cancer into Treatment Decision

Article
  1. Christine M. Walko, Pharm.D., discusses how advancements in technology have improved the quality, cost and turnaround time for assessing genetic mutations in tumor tissue, and how this has helped to translate precision medicine into standard clinical practice.
  • Read more about Translation of Molecular Genetics in Lung Cancer into Treatment Decision

Divergent Paths for Tagrisso (Osimertinib) and Rociletinib for EGFR T790M Mutation-Positive NSCLC and Acquired Resistance: What Happened, and Where Are We Now?

Article

 

  • Read more about Divergent Paths for Tagrisso (Osimertinib) and Rociletinib for EGFR T790M Mutation-Positive NSCLC and Acquired Resistance: What Happened, and Where Are We Now?
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Rociletinib/Osimertinib for EGFR T790M-negative NSCLC

Video

Dr. Jack West, Swedish Cancer Institute, reviews trial evidence for the efficacy of rociletinib and osimertinib for EGFR acquired resistance not driven by a T790M mutation.

  • Read more about Rociletinib/Osimertinib for EGFR T790M-negative NSCLC

Panel Q&A Session on Sequencing EGFR Treatments with Drs. Riely and West

Video

Drs. Jack West and Greg Riely field questions about which treatments should EGFR lung cancer patients consider when their cancers progress.

  • Read more about Panel Q&A Session on Sequencing EGFR Treatments with Drs. Riely and West

Treatment Options for EGFR T790M Negative Acquired Resistance

Video

Dr. Jack West suggests that progression in T790M-negative EGFR lung cancer patients may not require a change in therapy. In this video he details what should go into the decision to modify treatment for those patients.

  • Read more about Treatment Options for EGFR T790M Negative Acquired Resistance

Emerging Options for T790M-Positive Acquired Resistance

Video

Acquired resistance in EGFR patients is often driven by the T790M mutation. T790M-positive tumors respond differently to treatments than T790M-negative tumors. Dr. Greg Riely details how each status can predict patients' responses to current treatments.

  • Read more about Emerging Options for T790M-Positive Acquired Resistance

Are There Clinically Significant Differences Among the Third Generation EGFR Inhibitors?

Article

Drs. Ben Solomon, Leora Horn, & Jack West compare the clinical data with the third generation EGFR TKIs so active in acquired resistance and consider whether there are significant differences between them.

  • Read more about Are There Clinically Significant Differences Among the Third Generation EGFR Inhibitors?

Are There Clinically Significant Differences Among the First and Second Generation EGFR TKIs (Iressa, Tarceva, Gilotrif)?

Article

Drs. Ben Solomon, Leora Horn, & Jack West review whether the data and clinical experience suggest any clinically significant differences among the first and second generation EGFR TKIs (Iressa, Tarceva, Gilotrif/Giotrif).

  • Read more about Are There Clinically Significant Differences Among the First and Second Generation EGFR TKIs (Iressa, Tarceva, Gilotrif)?

Should Third Generation EGFR Inhibitors Be Used Before First Generation EGFR TKIs or After Progression?

Article

Drs. Leora Horn, Ben Solomon, & Jack West consider whether third generation EGFR TKIs, so active in patients with acquired resistance, might be best used prior to development of acquired resistance.

  • Read more about Should Third Generation EGFR Inhibitors Be Used Before First Generation EGFR TKIs or After Progression?

Clinical Trial Spotlight: Options for EGFR Mutation-Positive Patients with T790M Mutation-Negative Acquired Resistance

Article

Dr. Jack West reviews treatment options for patients with an EGFR activating mutation and acquired resistance but no T790M mutation, focusing on a clinical trial with the novel hypoxia-induced pan-HER inhibitor TH4000.

  • Read more about Clinical Trial Spotlight: Options for EGFR Mutation-Positive Patients with T790M Mutation-Negative Acquired Resistance

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    • Find Clinical Trials
    • Glossary
      • Cancer FAQs
  • EDUCATE
    • Current Patient Education Video Series
      • ASCO Lung Roundtable
      • Bladder Cancer Video Library
      • Blood Cancer Video Library
      • Cancer Information for the Latino Community
      • Case Based Panel Discussions
      • Clinical Trials Experiences Through Storytelling
      • Covid-19 and Cancer
      • East Asian Lung Cancer Video Library
      • HPV Advances - A Patient Education Program
      • Head and Neck Cancer News and Updates ASCO / ESMO
      • Lung Cancer Video Library - English
      • Lung Cancer Video Library - Spanish
      • Lung OncTalk
      • Melanoma Video Library
      • Patient Education Ambassador Program
      • Targeted Therapies Patient Forum - English
      • Targeted Therapies Patient Forum - Spanish
      • Testing and Early Diagnosis
    • GRACE Podcasts
    • Video Library
      • English
      • Spanish
      • Mandarin
  • PARTICIPATE
    • Community Forum
      • Bladder Cancer
      • Blood Cancer
      • Brain Cancer
      • Breast Cancer
      • Colorectal Cancer
      • Gall Bladder and Bile Duct Cancer (Cholangiocarcinoma)
      • Head and Neck Cancer
      • Kidney Cancer
      • Lung Cancer
      • Melanoma
      • Member Updates
      • General Forums
      • Ask A Question
    • Get Involved
      • Memorials and Tributes
      • Volunteer Opportunities
  • ABOUT CancerGRACE
    • GRACE NEWS AND INFO
      • Contact Us
      • How (and Why) to Use GRACE
      • GRACE Public Disclosure Documentation
    • About GRACE
      • Mission
      • Opportunities
      • Terms of Use
      • Our Supporters 2020
    • Our Team
      • Faculty
      • Staff and Board
    • Partnerships
      • GRACE and Clinical Care Options Patient Tools
      • Varian Partner Page 2020
      • Takeda Oncology Partnership Page 2020
      • Lilly Oncology Partner Page
  • DONATE
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      • More Ways to Give
      • Corporate Giving Programs
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      • Shop and Search for the Cause
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