Continued from part 1 Dr. West: You have a huge portion of your patients who have an EGFR mutation and we know that over time patients develop acquired resistance. So how do you approach the patients who have a great response initially, have a known EGFR mutation, and then you see that slipping away at slow progression? Do you continue the EGFR inhibitor? Do you add something to it? Do you change the dose? How do you approach that?

A couple of months ago I highlighted some very encouraging early work on the novel agent PF299804, an "irreversible pan-HER tyrosine kinase inhibitor".

In my last post, I described the novel oral agent PF299804 (PF299), an irreversible "pan-HER" inhibitor not only of the epidermal growth factor receptor but of other members of the human epithelial growth factor receptor (HER) family.