lstevens
![]()
Posts:1
I am seeking second-line treatment for NSCLC with mets to liver. Would like to join an immunotherapy trial, but concerned it may worsen my psoriasis. Any known information about this? Also, it appears some of the trials exclude autoimmune diseases. For purposes of qualifying for a trial, would psoriasis likely be an issue?
Forums
Reply # - December 11, 2013, 06:30 PM
Reply To: Immunotherapy with Psoriasis
The short answer to your questions is that we don't know. Worsening of autoimmune processes, including psoriasis, is a leading concern with immunotherapy trials, and yes, many trials exclude patients with autoimmune diseases. However, many people have a very mild version of autoimmune diseases, so in the past I've needed to ask the people running the trial whether a particular person's issues exclude them from an immunotherapy trial or not. It always ends up as a judgment, either by the people running the trial, the investigator enrolling at that center, or a combination.
I wish I could offer a more clear answer, but this is still a very gray area as we learn more, but with very little follow-up or published information.
Good luck.
-Dr. West
Reply # - December 12, 2013, 11:25 AM
Reply To: Immunotherapy with Psoriasis
In the original trials with Yervoy (ipilimumab) it is true that systemic psoriasis was largely excluded.
However, in many of the current PD-1/PD-L1 immunotherapy trials, cutaneous psoriasis or eczema is often allowed, providing it is controlled with topical medications, and does not require oral steroids. There may be a couple cases of psoriatic issues with these type of drugs, but they are very rare.
Hope this helps.