After over a year on crizotinib, a week ago my CT scan showed my lung nodule has increased by 1 cm in 8 weeks to 3.0 cm. and the PET showed that it is now an active lesion. And also, 3 small brain mets were discovered in September, so in October had the mets radiated. So, I have acquired resistance. As of now all that's left is this original lung nodule, which never really decreased in size much at all while on crizotinib, but basically remained unchanged. Radiation to the lung is now scheduled for the end of December. I am still taking crizotinib, and will go off temporarily during radiation treatments. Than advised to go back on crizotinib upon completion of the lung radiation. The question is, after completion of radiation to the lung nodule, would crizotinib still be the best treatment to stay on, even though it no longer kept the lung nodule from progressing and I had gotten brain mets? Some of the posts and videos suggest moving on to a different drug. But I did not find anything saying to stay on crizotinib after acquired resistance and disease progression. Thank you.
Fri, 12/11/2015 - 08:37#1
Progression on Crizotinib, upcoming lung radiation, continue crizotinib? - 1272162