My dad's lung tumor progressed a lot in 3 months (from 2.9 x 2.8 to 14.6 x 3.5cm) while on Tagrisso. He has t790m mutation and has been on Tagrisso since July. I would like to know if any NEW clinical trials available now to target his mutation?(where?) Is it necessary to do re-biospy?
his treatment history:
1. Tarceva for 9 months
2. CO1686 for 7 months --> progressed to leptomeningeal metastases
3. tarceva pulse + carbo/alimta/avastin for 7 months (brain met stable)
4. Tagrisso for 5 months (2-month MRI stable; no MRI scheduled this time, but no significant neurological symptoms)
Because my dad has history of leptomeningeal metastases, I would like to know if Tagrisso can be used in combination with Opdivo or chemo? How about Tarceva Pulse with Opdivo? What is the most recent clinical data for immunotherapy on patients with EGFR mutation? Should he consider chemo first before immunotherapy if immunotherapy is not effective on EGFR+? Any suggestions on the chemo drugs?
Any feedback and suggestion is greatly appreciated.