xalkori - 1292416

From a previous post and still accurateDr. West states, "The dosing recommendations are that if the “transaminases”, which are listed as ALT and AST, are more than 5x the “upper limit of normal” (ULN) at that particular lab, and the bilirubin level is less than 1.5x ULN, then the dose should be reduced to 200 mg by mouth twice daily once the AST and ALT are less than 2.5x ULN. If the ALT and/or AST numbers are elevated and the bilirubin is higher than 1.5x ULN, the guidelines say to discontinue the drug." http://cancergrace.org/topic/xalkori-side-effects#post-1246670

I hope you do well.
All best,
Janine

Hi dozivivise,

There's really no way to put a time frame on it. As Dr. West has said:

"Obviously, the idea is to drop to a level where there is no elevation in the liver enzymes, or the level of elevation is limited enough that it isn’t a significant concern. Unfortunately, however, there’s no way to know in advance whether the lower dose will still lead to elevated liver enzymes or not. You just need to see what happens after trying it." - http://cancergrace.org/topic/xalkori-and-increased-liver-enzymes

I hope the dose reduction works well for you.

JimC
Forum moderator

I think you're asking if artichoke syrup has a lower glycemic index than other sugars and that is beyond the scope of Grace. I didn't find any info that says anything other than suggests it would be better than other types of high fructose syrups and that was from those selling it.

Hello! Does anyone here knows where there is a clinical trial. For Xalkori on a newly diagnosed patient?

Hi donnadc,

Welcome to GRACE. The best place to find clinical trials in your area is to search clinicaltrials.gov. I searched for Xalkori trials for lung cancer patients (without specifying a location, since I don't know yours), and found 75 studies. Entering your location in the search criteria would likely reduce that to a more manageable list.

JimC
Forum moderator