My wife was on Tarceva for over 6 1/2 years. Then she developed acquired resistance to Tarceva with prevascular and supraclevical lymph nodes enlargement. Gene sequence on the biopsy of the large prevascula node revealed negative to T790M, PD-1 and PD-L1. Because the speed of which the lymph nodes are increasing in size she was quickly given 6 cycles of Carboplatin/Alimta. The cancer responded to the chemo exceedingly well. 7/24/2018 CAT scan of her body shown both lymph nodes reduced to negligible normal size. She was put on Alimta maintenance every 3 weeks. However, since Jan 2018, her former excision site in her right occipital lobe began to show signs of necrosis or recurrence. Question: Can Tagrisso be used in conjunction with the Alimta for better penetration of the BBB for potential brain/CNS involvement.
Mon, 10/01/2018 - 17:51#1
Can Tagrisso be used in additional to Alimta maintenance