Stopping Chemotherapy with Stage IV NSCLC - 1271623

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My Mother-in-law was diagnosed with Stage IV NSCLC in January 2014. She is 87 years old. She recently stopped chemotherapy (Carboplatin and Docetaxel) as it was too much for her body to handle. Her oncologist based her chemo treatment on CEA blood test only. After her final chemo treatment her CEA level went from 313 to 664.6. She seems fine right now other than not being able to walk a small distance without being out of breath. I am her sole caregiver and I don’t know what my next step should be since she is stopping treatment.

Worried sick about Pancoast Tumor - 1271620

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Im 38yr old, 20yr smoker. (I know, I know) I have had right sided chest pain that shoots through to my back for the last 5yrs. I have been through an array of tests/scans over the years. Only thing that shows ups are scattered tiny 5mm or less lung nodules, (which scare me to death) I should note, when this pain started so did a brown sputum production that only comes from the right side of my chest, so I have always thought this pain was Lung related due to the sputum.

Chemo delay a good idea? - 1271606

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My husband was diagnosed with 3b NSCLC in early July. He's finished 3 hits of Cisplatin/Alimta and has delayed his next treatment because he couldn't eat and didn't feel up to it.

One oncologist told us it didn't matter if he delayed the treatment because it wouldn't make much difference. (Doing the 4th chemo early next week so it will be 5 1/2 weeks between the 3rd and 4th treatment.)

A 2nd doctor told us the risk with delaying chemo was the cancer would progress and then they would have trouble getting it under control.

Brain Mets: Progression vs Necrosis - 1271602

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- 59-year old female, never smoker
3/4/2013: diagnosed with stage 4 NSCLC Adenocarcinoma EGFR+, 4 brain mets (1.7cm, 1.3cm, 2mm, 2mm), 3.5cm lung nodule
3/19/2013: Cyber Knife (all mets resolved within a few short months)
4/19/2013: Tarceva 150mg
11/21/2013: VATS lobectomy
3/10/2014: Tarceva 100mg
9/5/2014: new 2mm brain met
11/19/2014: now 4mm brain met treated with Cyber Knife. Resolved in a few months.
12/21/2014: Tarceva 75mg

Opdivo - 1271598

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My wife has NSCLC in both lungs. Stage 4 pretty bad. Normally on Oxygen 3 liters when at rest and 4-5 when walking or active. This normally is the case. Friday she had her first treatment with Opdivo. The new
immune-o-therapy drug.

24 hrs latter her Oxygen is 99 % at rest with 2 - 3 litters but soon as she stands and walks a few feet it drops quickly into the 70's and takes about 1 -2 minutes of rest to come back up to 99%. Stays there as long as she is at rest.

Needless to say going to the bathroom is a chore.

Doubling Time -> Aggressive or not? - 1271596

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I have a metastasis to my lung that has grown from 6 mm in June to 9 mm in September, over a period of exactly 99 days. I got online and put the information into Doubling Time calculators, and the doubling time is about 53-56 days.

Question: is this rate of growth considered aggressive cancer? I looked on the internet but wasn't able to find an answer to this question. I also know that aggressive cancer is typified by other characteristics, such as how well-defined the cancer cells are, but for my basic purposes, I was wondering what the Doubling Time of my cancer indicates.

NED for 21 months, stop GILOTRIF? 2 Questions to Dr West - 1271594

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I have been living for many years in Austria (Europe) but I come originally from Iran, I am a 45y female, non smoker and we had never any cancer case in our family.
01/2014: I fell down and broke my spine; surgery showed bone metastasis in the 8. spinal column. Cancer cells were removed during surgery then spondylosis T5-T8.
01/2014 : Biopsy from lung, diagnosis: stage IV NSCLC with EGRF exon 21 (right upper lung: 2cm size)
02/2014: started GILOTRIF 40mg
02/2014: 26 cycles of radiation of spine bones

progression on co-1686 with brain met - 1271564

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Brief info about my dad: he was diagnosed stage IV NSCLC w/ EGFR+ in March 2014; He was on Tarceva until March 2015, then found t790m mutation & started clovis drug co-1686; June CT scan showed slight progression; July scans showed further slight progression and 6 brain met; he has 2-day cyberknife treatment on August and was allowed to remain on the trial; Suspicious more brain met on Sept MRI, watch and wait; total 7 more small brain met confirmed on Oct MRI and 6 previously treated brain met shrunk; he started having symptoms in the past 2 months (pain on the rib, cough, shortness of

leptominengial carcinomatosis - 1271552

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Hello,
I am very concerned that I might develop leptominengial carcinomatosis.
At the time of diagnosis I already had 9 brain metastases from a stage IV EGFR pos non small cell adenocarcinoma of the lung.
I was told that the brain mets where synchronous.
Tarceva got them down to 3 (visible on MRI ) mets , and these got treated a few weeks ago with SRS
I never had WBRT even though that was one possible and recommended treatment at the time.

Carcinoma Unknown Primary Stage IV - liver, lungs, chest, pancreas - 1271549

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Can you interpret PET Scan for me for father? Stage IV Unknown Primary - has pneumonia now and fluid in abdomen. Impression: PET/CT findings consistent with widespread FDG avid metastatic involvement through out the neck, chest, and abdomen, including extensive FDG avid lymphadenopathy, hypemetabolic pulmonary metastatic disease, and FDG avid hepatic involvement. Splenomegaly. Diffuse increased FDG uptake throughout the marrow of the axial and appendicular skeleton, without definite correlate on the bone windows, which is nonspecific, possibly related to reacive marrow hyperplasia.

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