The ALK mutation came back negative. According to the report there weren't enough cells that presented with the mutation for it be considered positive for ALK. HOWEVER, 63% of the cells tested "suggests ALK gene apmlification or plysomy of chromosome 2. The clinical significance of ALK gene amplification or chromosome 2 polysomy in patients with NSCLC is uncertain. Polysomy is not currently an indication for crizotnib therapy."
What exactly does this verbiage mean? Is there an ALK mutation present or not? what is amplification? and what is chromosome 2 polysomy? are these treatable with targeted therapy or immunotherapy? where can I go to research these specific details? are there clinical trials that work on this specific situation? or certain docs across the nation that are experts in this field?