Hello! Husb (StgIV adenoALK+, brain mets) started Alectinib 11/16 as Crizotinib for 19 mo had not appreciably diminished multiple brain mets (despite WBR and Gamma knife) During 19mo of treatment no new brain mets (and no lung/extra cranial mets either) He had his first, brief seizure 4 wks after Alectinib started. CT showed no significant change from 10/16, so await MRI in mid 2/17. Theorized by onc MD that perhaps getting better CNS penetration with this new med, resulting in inflamm changes, leading to seizure? Now on Keppra for seizure prophylaxis. Wonder if any others have ideas/experiences with Alectinib?
Fri, 02/03/2017 - 14:43#1
Alectinib after Crizotinib. Others' experiences? - 1289972