Not long ago I posted a very upbeat message of hope to the lung cancer community. My sister, a ROS1 positive nsclc patient, had had a seemingly miraculous response to crizotinib: after two cycles she was nearly her old self again and we were ecstatic. At the time, I did express concern about resistance, but many respondents encouraged me to remain optimistic.
My sister suddenly became symptomatic again two weeks ago. Her doctor concluded that crizotinib was no longer effective and Sara began a two-week "wash out" period necessary to transition to the next drug, ARIAD 26113. We were told that she will be her doctor's first ROS1 patient to try the drug.
So, my question is this: does anyone know of other ROS1 patients who have become resistant to crizotinib and who are now trying ariad 26113? If so, how long have you been on it and how is it going? What are the side effects? Any insights will be deeply appreciated.