Hello, wondering if this is a red flag that needs attention. Have been on Crizotinib for 5 months. ALK positive, nsclc, stage 4. (age 59, non-smoker, health nut type, fitness freak, etc.) Lung tumor stable and small, and I feel great, with the exception of being dizzy or light headed since taking criz. This dizzyness is all day long. Have had EKG's every 6 weeks to monitor since going on drug, and heart rate has been decreasing each time, with a note on each report: "Marked Sinus Bradycardia". Heart rate is now in low 50's and a few high 40's since began taking Criz. whereas formerly in my life it ran in 60's and 70's . I am not taking any concomitant medications. QT and QTc are normal. The Xalkori prescribing information brochure has a table (Table 2) of "dose modification", one of the criteria is bradycardia, which they define as less than 60 heart beats per minute. The table says "withhold until recovery to asymptomatic bradycardia or to a heart rate of 60 bpm or above." or "..resume at redduced dose upon recovery to asymptomatic bradycardia or to a heart rate of 60 bpm or above." Has anyone had this low heartbeat/bradycardia, and have you gone off the Xalkori, or taken a reduced dose, for how long? I am the first patient my onc. has had on this drug.
Wed, 10/15/2014 - 21:26#1
Bradycardia - Crizotinib / Xalkori side effect - reduce dose - 1266510