Hi, I hope someone from this great community can help. My mom was diagnosed with Stage 4 NSCLC 3.5 years ago. At the time of diagnosis she tested positive for EGFR l858r and was subsequently put on Tarceva which lasted a little over a year before she progressed. Went on Tagrisso for about 1.5 years. She recently tried carbo/alimpta/Keytruda but discontinued in March this year since she was still progressing after 3 rounds. She’s been back on Tarceva for about a months now. She seemed to have responded after two weeks since her health improved however things have been going in the wrong direction now.
She recently had liquid biopsy and the result showed EGFR, TP53, T790m, and RB1. What does this mean? Google keeps turning up SCLC transformation. At this point does her liquid biopsy indicate a need to change treatment?