I was forst diagnosed in June 2012 after 2 P/E one in Jan, 2012 the other in May 2012.
I had a resection of the duodenum (small intestine) in June 2012 followed by One round of Flolfox (11 trmnts) and 2 rounds of Folfiri. I am now on a third round of Folfiri. My Oncologist tells me the Folfiri is not curative and serves only to keep the cancer in check. The cancer is restricted to a few lymph nodes near the re-section site w/o metastases to other organs.
Unfortunately each time I went off chemo I suffered either a DVT (1) or a P/E (2) making a total of 4 P/Es
The last two were near fatal. I have 'failed coumadin' twice and LMH (Fragmin) twice. Once on a dose of 17.5K units per day and the second on a dose of 22.5K units/day on a split dose. I have an IVC filter in place which is clogged with clots.
I am currently on a dose of 27.5K units LMH split dose/day. My Oncologists and hematologist tell me the only way to prevent the clotting is to remain on chemo for life.
Although my doctors do not agree - I believe I have failed both coumadin and Fragmin. They offer no alternative other than the chemo. I was over therapeutic range on both of my last 2 P/E's and the DVT.
I am inclined for Quality of Life issues to switch to one of the newer oral anti-coagulants and take breaks on the chemo appropriate to my life style. Are there new anti-coagulants for cancer induced clots which i can discuss with my oncologist?