My mother ( Age :44 years, non smoker) diagnosed with adenocarcinoma on april 2014...she underwent 6 cycles of Gemcitabine+Cisplatin chemotherapy as her first line....the pet ct showed an excellent response and it showed 80% tumor size reduction and one in her 12th rib...so our on suggested to go for imrt with chemo...so she was given 30 imrt sessions to her lung tumor along with 12 sessions for rib...she was also on carboplatin and etoposide chemotherapy....after completing 4 cycles of chemo, she underwent an ischaemic stroke in her left brain...incidentally, we also found there was a lesion on skull bone small in size and brain was clear....
1) Does this indicate progression on second line??
2) is it possible for her to be on alimta and avastin maintenance although her first two lines were different??
3) is it possible for her to have the same response of alimta to never smokers in her third line???
Is it possible to have Alimta/Avastin in my mother's case??? - 1268479
raghav93
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Reply # - February 13, 2015, 09:41 PM
Yes, I'm sorry that the new
Yes, I'm sorry that the new bone lesion sounds like it should represent progressing disease, if it's real.
Because Avastin (bevacizumab) is associated with a greater risk of clotting as well as bleeding complications, it would not generally be favored for someone with a history of a recent stroke. There would be great concern about the risk of causing worse complications with Avastin.
There is no particularly remarkable efficacy of Alimta (pemetrexed) in never-smokers. It is often a very helpful agent for patients with non-squamous NSCLC, perhaps especailly adenocarcinoma, but smoking status isn't a clearly relevant factor.
Good luck.
-Dr. West