Metastatic spinal cord compression - 1246506

aup2011
Posts:2

Most commonly the spinal cord compression occurs secondary to posterior extension of a vertebral body mass - do you consider a cord compression a clinical progresion or a radiological progresion and report it as a new lesion in RECIST data? Thanks in advance for your respone!

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Reply # - August 8, 2012, 02:08 PM

JimC
Posts: 2753

Hi aup2011,

Perhaps you could clarify your question. Bone lesions are considered non-measurable for RECIST purposes, so I'm not sure what distinction you're making. If there is evidence of pain which appears to be cancer-related that's certainly a clinical finding, but if something shows up on a scan there is radiological evidence of progression if it's suspected to be cancer-related, but whether it could be called a "new lesion" I wouldn't think so, especially if all that can be seen is the compression, not the tumor.

JimC
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Reply # - August 8, 2012, 10:07 PM

Dr West
Posts: 4735

It has to do with the specific rules of the RECIST criteria, which I'm pretty sure are based on visualized changes. If there were clinically worse symptoms but no evidence of visible changes on scans, it wouldn't meet criteria for RECIST-defined progressive disease...though it would represent clinical progression.

-Dr. West

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