Osimertinib (Tagrisso) with dexamethasone

Hi Daxys,

Welcome to GRACE. It's best to discuss your concerns with your oncologist, but in the meantime if you look at the physician desk reference page on Tagrisso, which exhaustively lists all the drug interactions that are significant enough for doctors to take into account, it doesn't list dexamethasone or decadron.

See: http://www.pdr.net/drug-summary/Tagrisso-osimertinib-3828

Drugs can have weak interactions but not enough to change how medications are prescribed or patients monitored.

Since Tagrisso crosses the blood brain barrier, hopefully your Mum has a good response and it will shrink the mets in the brain so your Mum may not need to stay on Dexamethasone. Sometimes Tagrisso is prescribed at double dose (160 mg rather than 80 mg) for patients with brain mets.

Hi daxys,

I'll add my welcome to GRACE, as well as a bit more information in addition to what onthemark has already provided.

The interaction between osimertinib and dexamethasone is one which is predicted because dex is a weak CYP3A inducer. As onthemark points out, trial experience hasn't revealed enough of an interaction to warrant including dex interaction in the prescribing information for Tagrisso. In a study of such possible interactions, it was concluded:

Based on observed clinical data and PBPK simulations, the recommended dose of osimertinib when dosed with strong CYP3A inducers is 160 mg once daily. PBPK modeling suggested no dose adjustment with moderate and weak CYP3A inducers. - https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12289

Although we wouldn't expect an interaction of any significance, at worst the dosage of either Tagrisso or dexamethasone would simply need to be adjusted.

Good luck to your mum with Tagrisso!

JimC
Forum moderator