Dear Doctors and Moderators!
could you please advise where to go after dramatic progression in bones and lungs on Tagrisso .
first line: carboplatin alimta avastin didn’t work at all
second line: tarceva worked perfectly for 9 months them progressed in lung and bones
third line: Tagrisso without t790m worked perfectly and clear both lungs for 5 months
now is dramatic progression in bones and lungs .
Tissue biopsy showed my original l858r mutation.
Could you please advise what could be the next. I am afraid to start chemo again because the first one didn’t work for me .
many thanks in advance ❤️