Tagrix vs Tagrisso

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edina81
Tagrix vs Tagrisso

Dear,

please for support with aim to check experience with Tagrix in threrapy of NSLC stage IV after Tarceva therapy. I have pointed Tagrix as Tagrisso is not available in my country. Any experience with this drug, know this is generic version.
Thank you.

Jim C Forum Mod...
Jim C Forum Moderator's picture
Hi edina81,

Hi edina81,

Welcome to GRACE. Tagrisso and Tagrix are two of the brand names under which the drug Osimertinib is marketed in different parts of the world. Since this is a recently developed drug, there is no generic form available, and won’t be for quite a while, until the patent for this medication runs out.

As a result, any information you have seen about the efficacy of Tagrisso will apply to Tagrix. Tagrisso has been shown to be effective for patients who have progressed on treatment with Tarceva if they have developed a T790M mutation. If you search this site for the term “Tagrisso” you will find plenty of information regarding its use and efficacy.

JimC
Forum moderator

edina81
Dear Jim,

Dear Jim,

thank you for the reply. I was little bit concerned about Tagrix as it is generic medicine, and as I work as MD and for years following clinical trials I was skeptic somehow. Is there anybody on this medicine present in some groups for consultation?

Thank for the support in this difficult period.

BR
edina81

catdander
edina81,

edina81,

There aren’t many members at this time on Grace who chat on this forum, though it would be great if there were. Forums such as Lungevity that have a large member community that would probably have members who take Osimertinib under the brand name tagrix. As Jim said both tagrix and tagrisso are the same drug, osimertinib so info on tagrix should look exactly like info on tagrisso.

I hope you do very well.
All best,
Janine

jasonhay
I developed resistance to

I developed resistance to Erlotinib, which served me well for three years. I now have 4 months with Osimertinib and I feel much better, the side effects of diarrhea and rash are more tolerable and showed improvement to the RX. I can not afford for TAGRISSO, but Tagrix is almost the same as. Hope more people know the cheap Tagrix.

catdander
I’m sure tagrix isn’t

I’m sure tagrix isn’t avialable in the US and other countries who follow the same patent laws.
I’m so glad you are getting the drugs you need and know you are thrilled to be rid of the worst of the side effects. Hope you are on this for a long long time.

All best,
Janine

jasonhay
Thank you so much for your

Thank you so much for your kindly and detailed reply.
Edit by Janine, “I’m so sorry but I have to edit out the link but I’m sure anyone who doesn’t have access to the brand name can use what has already been given or better yet talk to your doc or one of their team to help you get the treatment you need.”

edina81
Dear all,

Dear all,
thank you for the support and advises, appreciate it so much. I have investigated a lot among those two medicines, and generic compound is same, so no medical issues to take it. We already ordered generic drug directly from the manufacturer and I will keep you updated on progress.
Hope this will help. God bless all of us! E.

catdander
Thank you for the update

Thank you for the update edina81 and best of luck on your new treatment.

Janine

nagraj1970
Hi edina81 – Is there any

Hi edina81 – Is there any further update on progress. Thanks

edina81
Hi, I do not know what to

Hi, I do not know what to answer. He has been given 4 cycle Alimta+ Cisplatin after Tarceva, started with Tagrix month ago. Hope medicine will work as for now it is too early. I have contacted manufacturer, found some web sites, checked Bangladesh Drug Agency- seems it is legal and OK. Would realy like to know more,and others experience as for us it is too early to share any valuable info. Anybody with additiinal info?

daxys
Some people from inspire.com

Some people from inspire.com

https://www.inspire.com/groups/american-lung-association-lung-cancer-sur...

are using Tagrix with success – Satsbefast, YunC (whose mum also took generic Irressa with success for 1-2 years, now she has been on Tagrix for 1-2 years) , Brtmnbs (his wife had a really great response on Tagrix, it almost cleared her lungs). I checked with those people before buying Tagrix for my mum. YunC told me that in China most people use generics.
My mum has been on Tagrix just for a couple of days. But unfortunately for her mutation (G719X) osimertinib does not seem that promising. We have to hope for some luck. If osimertinib does not work, I will have to buy generic Afatinib I guess (I will need to get some references for it first)

Anonymous (not verified)
Hello Everyone

Hello Everyone
I am on tagarisso since 4 months.Wanted to know if any one had success with tagrix.As my doctor is not commenting on this issue.
Thanks

Jim C Forum Mod...
Jim C Forum Moderator's picture
Hi seema2000,

Hi seema2000,

Welcome to GRACE. As stated earlier in this thread, Tagrisso and Tagrix are two different brand names for the same drug, with one name used in some parts of the world, and the other used elsewhere. They will work equally well.

Many patients respond well to this drug as you can see from the post just prior to yours, and other posts on this site. Just search for “Tagrisso”, as this is the name most often used to refer to the drug here.

I hope you have an excellent, lengthy response to Tagrisso.

JimC
Forum moderator

miamia
can someone tell me about my

can someone tell me about my mon case:( she has already taken the Tagrix for 2 months after she stopped Iressa. From the beginning everything seems like better. but now CEA gets more higher and so also has  pleural fluid :( is there anyone know abt this case? and have read about somebody who takes 2 tables per day. im not sure if it works or not. Could someone give me an advise? thanks so much

Jim C Forum Mod...
Jim C Forum Moderator's picture
Tagrix for two months

Hi miamia,

Many oncologists, including the GRACE faculty members, do not routinely use a rising CEA as firm evidence of cancer progression; it just doesn't tend to be reliable for most patients. And an increase in pleural fluid, though suggestive of progression, can be caused by other factors such as inflammation in the pleural cavity. So it would not be unusual for your mom's oncologist to maintain her dose at the current level and rescan at a reasonably short interval.

If you are suggesting the possibility of doubling the dose, the concern would be that the side effects might increase quite a bit without gaining much if anything in terms of efficacy.

Jim C Forum Moderator

 

miamia
Pembrolizumab (keytruda)

Dear Jim

Thanks for your reply. 

Currently, my mom is still taking Tagrix but it seems not positive. Doctors has recommend us to changing to chemotherapy. But it often causes very bad side effects. Do you have any advice for me in this case of resistantance to Tagrix? At the same time, the doctor advised us to consider the Pembrolizumab (keytruda) therapy, but according to what I have researched about, this therapy is only suitable for those who do not have EGFR mutations.
Looking forward to receiving your advice.

Jim C Forum Mod...
Jim C Forum Moderator's picture
Pembrolizumab (keytruda)

Hi miamia,

I'm sorry to her that your mom's oncologist has determined that Tagrix is no longer effective. If she tolerated EGFR TKI treatment well, I can understand your concern about a switch to chemotherapy. However, chemo often is no longer as toxic as it once was, and oncologists have more tools available to deal with the side effects that do occur. For example, many EGFR-positive patients do very well on pemetrexed (Alimta) with relatively few side effects. It is often considered one of the best-tolerated chemo agents available.

 

As far as pembrolizumab, it is certainly true that in general response rates for EGFR-positive NSCLC patients are lower than they are for other patients. On the other hand, EGFR+ patients with high PD-L1 expression can obtain a good response from the drug.

 

I hope that after further discussion with your mom's oncologist, you can choose a treatment plan that will be effective and well-tolerated.

 

Jim C Forum Moderator

 

masalovai
Hello JimC

Hello JimC

I am a bit confused….. As you mentioned in your first message: there is no generic available for Tagrisso because it’s relatively new drug on the market.

On other side: if those are same drugs made under different names ,than they both consider as original and need to be produced by the same company. Same like hypertension drug (valsartan) made as Diovan and Tareg but produced by Novartis and both considered as original with exactly same formulation.

In the case of Tagrisso and Tagrix , they are produced by different companies, so I think Tagrix could be considered as genetic drug….

Probably I am wrong…… This is very important question and we would like to understand in what extent we can trust those drugs.

Is there any chance to get professional opinion from oncologists and pharmasists who are dealing with patients daily and probably contacted producers of those drugs for some information .

masalovai
Can we probably contact Astra

Can we probably contact Astra Zeneca and confirm that production of Tagrix by the company in Bangladesh is legally patented…… what do you think ? Probably I am too naive….. Not sure how it works…..

daxys
I guess Jim’s reply might be

I guess Jim’s reply might be a little misleading here. Tagrix is generic osimertinib made in Bangladesh.
I dont think there is any agreement/contract between Astra Zeneca and Beacon. Third world countries do not have to abide by international patentation laws for medications and can produce generic medications under some kind of exception (which will expire in several years) . Thats what Beacon does.
I am afraid, we can’t consider all generic anticancer medications made in “developing countries” automatically to be equal to originals and if we want to use them, we should do our research and get some references on them. I believe, Tagrix can be considered a good generic medication based on very succesfull experiences of several patients on Inspire and on good reputation of the manufacturer – Beacon is a leading company in anticancer generics production.

masalovai
Hi, Daxis

Hi, Daxis

Thank you very much for the explanation. Personally I am happy that we all can have an access to affordable drugs. I also read good opinions about Tagrix in inspire .

Jim C Forum Mod...
Jim C Forum Moderator's picture
Hi daxys,

Hi daxys,

Thank you for clarifying my statement, as I didn’t address the issue of licensing. Essentially it comes down to a question of the quality of the product manufactured by Beacon-one of those questions that is tough to answer without a detailed lab analysis or head to head clinical trial comparison.

JimC
Forum moderator

masalovai
Thank you, Jim, for you

Thank you, Jim, for you valuable contribution to this discussion ( as always ).

Let us hope they are making good and affordable product and it can help many people to survive.

Wish to everyone good success with their treatment and many more active years ahead !

❤️

daxys
Osicent

There is also another generic osimertinib from Bangladesh named Osicent that seem to be also identical with Tagrisso and Tagrix. Some people in the "EGFR Resisters" facebook group took original and generic pills to laboratories for analysis and the result was tey were the same.
There is a guy in the same group who reports complete response on Osicent. You can go to "EGFR resisters" facebook group and search for Osicent. Osicent is half of the price of Tagrix.

JanineT Forum M...
Thanks daxys. Always good to

Thanks daxys. Always good to know the options throughout the world.