So it appears that after just 3 months of Gilotrif (afatinib), my mother may be having disease progression:
- increased bone pain
- "progression" of multiple diffuse bone mets on bone scan & CT chest/abd/pelvis
Although our oncologist says that he thinks the bone scan findings are due to new bone being laid down (Mom's on Xgeva), he has floated the idea of starting carbo/Alimta, if she can't get to a tolerable dose of Gilotrif. After a 2-week drug holiday due to really bad scalp irritation/seborrhea, we've started back at Gilotrif 40 mg every other day.
My question: if she can't stabilize on Gilotrif, or if there is progression, what's next? Do you favor one option over the other?
2. phase 2 trial of BI 1482694
4. Is Opdivo an option at all?
5. another oncologist suggested starting Tarceva, if Gilotrif fails...
Thank you all for your help, comments, time and sharing your invaluable experiences. I wish you the best,