Dear GRACE community --
I was wondering about this question and even tried to research it to no conclusive avail.
When does apoptosis occur following chemotherapy?
I know that it does not occur at one instant in time. I imagine there is a background rate of apoptosis, and that following a course of chemotherapy, this rate is temporarily enhanced for cancer cells (and other cells too.)
I know that each individual and tumor is different. I don't mind heterogeneity in the data -- I am looking for coarse estimates.
I did find following references,
I also reasoned that apoptosis might track with leukopenia following chemotherapy -- however, my understanding is leukopenia may occur at much longer time scales, and also may be imperfect correlate in the presence of myelosuppression.
What is known about the time-evolution of apoptosis following chemotherapy?