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The next portion of Dr. Leighl's "Highlights of Lung Cancer from 2012" webinar focused on exciting research presented at ASCO 2012 and very recently published on the potential efficacy of a new class of targeted therapy, called MEK inhibitors, for the large subset of patients who have a KRAS mutation. KRAS is the most common mutation seen in lung cancer, found in about 20-25% of patients with NSCLC, in different histologies and with different smoking histories, but we haven't had an effective therapy for this group of patients, in whom some evidence suggests that both EGFR inhibitors and standard chemotherapy are less effective.
Dr. Leighl's podcast discusses encouraging work that suggests a potential value in adding a MEK inhibitor to standard chemo, though ensuring that it's a tolerable combination is something we'll need to continue to work on (in addition to confirming the activity of MEK inhibitors in larger trials). Here's her presentation in video and audio format, as well as the figures for it.
[powerpress]
Dr. Leighl Highlights in LC 2012 Pt 3 MEK for KRAS Mutn Audio Podcast
Dr. Leighl Highlights in LC 2012 Pt 3 MEK for KRAS Mutn Figs
Dr. Leighl's Highlights in Lung Cancer, 2012 program next turned to squamous cell carcinoma and anti-PD1 immunotherapy work, so look for that here very soon. In the meantime, I hope you find this program helpful and promising!
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Hi elysianfields and welcome to Grace. I'm sorry to hear about your father's progression.
Unfortunately, lepto remains a difficult area to treat. Recently FDA approved the combo Lazertinib and Amivantamab...
Hello Janine, thank you for your reply.
Do you happen to know whether it's common practice or if it's worth taking lazertinib without amivantamab? From all the articles I've come across...
Hi elysianfields,
That's not a question we can answer. It depends on the individual's health. I've linked the study comparing intravenous vs. IV infusions of the doublet lazertinib and amivantamab...
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