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This week, the US FDA made a public announcement to alert the public that it had received reports of several patient deaths from the technique of radiofrequency ablation (RFA) to lung tumors. This is an investigational technique that I described in a prior post, after several members asked about RFA. I made the point that while it was an option to consider, it was still early in development and was not an option that I thought would be a leading option except in very unusual circumstances. You heard it here first...
There have been some individuals and centers that have been liberal in their marketing of this technique, including for lung tumors. The FDA warning highlights the danger of marketing hype getting ahead of the evidence supporting the safety and clinical benefit of a new technique or drug, which really need to be subjected to thorough clinical testing. These trials are well regulated and closely monitored, and their results will move the field forward. Accordingly, the FDA warning mentions that RFA should preferably be conducted on lung tumors in the setting of a clinical trial.
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Dr. Singhi's reprise about appropriate treatment, "Right patient, right time, right team".
An antibody–drug conjugate (ADC) works a bit like a Trojan horse. It has three main components:
Bispecifics, or bispecific antibodies, are advanced immunotherapy drugs engineered to have two binding sites, allowing them to latch onto two different targets simultaneously, like a cancer cell and a T-cell, effectively...
The prefix “oligo–” means few. Oligometastatic (at diagnosis) Oligoprogression (during treatment)
There will be a discussion, “Studies in Oligometastatic NSCLC: Current Data and Definitions,” which will focus on what we...
Radiation therapy is primarily a localized treatment, meaning it precisely targets a specific tumor or area of the body, unlike systemic treatments (like chemotherapy) that affect the whole body.
The...
Biomarkers are genetic mutations (like EGFR, ALK, KRAS, BRAF) or protein levels (like PD-L1) in tumor cells that help guide personalized treatment, especially NSCLC, directing patients to targeted therapies or immunotherapies...
Welcome to the new CancerGRACE.org! Explore our fresh look and improved features—take a quick tour to see what’s new.
A Brief Tornado. I love the analogy Dr. Antonoff gave us to describe her presentation. I felt it earlier too and am looking forward to going back for deeper dive.