Here is the third and final case I discussed with two great experts in locally advanced NSCLC. Drs. George Blumenschein, medical oncologist from MD Anderson Cancer Center in Houston, and Wally Curran, radiation oncologist from Winship Cancer Center at Emory University in Atlanta, joined me several weeks ago to discuss a series of challenging cases that illustrate the complexities and array of options in treating patients with stage III NSCLC.

This case is a woman with bulky stage IIIB NSCLC that involves lymph nodes above the collarbone (supraclavicular lymph nodes) on both sides, putting her in the outer reaches of what we could envision being treated for cure. Our discussion includes consideration of the potential approaches, including the potential value of chemo before or after concurrent chemo and radiation. It also covers the difficulty of assessing response after treatment, and the risk of radiation pneumonitis.

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This program was made possible by a grant from OSI Pharmaceuticals. We are grateful for their support.