Second Line Chemotherapy for Advanced NSCLC: One Drug vs. Two

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One of the key points that has been established in first line treatment of advanced NSCLC is that two drug chemotherapy is superior to one drug chemo. Several trials from a decade ago showed that a two drug "platinum doublet" led to a longer overall survival than either a platinum alone (typically cisplatin at the time that these trials were performed) or another agent, such as paclitaxel alone.

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