I very much appreciate your opinion on the following:
I was diagnosed in February with poorly differentiated adeno, TTF1, asolated squamous cells p63. I have tumor on left upper lobe, a few lips nodes involved and bone mets.
I had 4 cycles of Carbo alimta avastin and it didn’t work for me at all. Progression with another lymph node and two more bone mets.
Then I had surgical biopsy and stereotactic radiation for all bone mets. Biopsy results show only L858R mutation.
So I am starting Tarceva ,but not sure if it will work for poorly differentiated tumor with squamous component ...?..
If it doesn’t work what could be the next option?
Probably immunotherapy would work better fo4 this type of tumor or combination of TKI and immuno drug.
My pd-l1 is negative, but I know that it is not indications of response to immunotherapy.
Could I have your thoughts please.