Partial Progression

CDaniele
Posts:1

When there is evidence of successful therapy of EGFR with TKI in one area of the lung but suggestion of progression in another area, what is the next best diagnostic path? My impression is that this scenario would yield probabilities we could test, such as the likely nature of the second mechanism.Is it not true that progression is most likely a global failure of the first TKI therapy?

JanineT GRACE …
Posts: 628
GRACE Community Outreach Team

Hi CDaniele,
Welcome to Grace. If the TKI is working except for one or 2 places local treatment such as radiation can be used to get rid of the resistant cells. This can allow the person to continue with the same TKI. The goal here is to use a treatment for as long as possible and keep other treatments for the future. This is an excellent video with Dr. Weiss to explain this treatment. https://cancergrace.org/post/local-therapy-limited-acquired-resistance
I hope this helps. Let us know if there is something I've missed or something else we can help you with.
Take care,
Janine

I joined GRACE as a caregiver for my husband who had a Pancoast tumor, NSCLC stage III in 2009. He had curative chemo/rads then it was believed he had a recurrence in the spine/oligometastasis that was radiated. He's 10 years out from treatment.

JanineT GRACE …
Posts: 628
GRACE Community Outreach Team

I forgot to tell you that Grace is having its annual OncTalk live forum online Saturday, Dec. 11 at 8 am Pacific and 11 am Eastern
It will be invaluable to anyone with or caring for someone with lung cancer. https://cancergrace.org/post/register-now-onctalk-2021
It's free and you'll have the opportunity to ask our faculty questions.

I joined GRACE as a caregiver for my husband who had a Pancoast tumor, NSCLC stage III in 2009. He had curative chemo/rads then it was believed he had a recurrence in the spine/oligometastasis that was radiated. He's 10 years out from treatment.